顆粒酶B活性檢測試劑盒

Granzyme B Activity Assay Kit

產(chǎn)品編號：

3092676

產(chǎn)品類別：

試劑盒

純度規(guī)格：

Sufficient for 100 Fluorometric tests

包裝規(guī)格：

1 KIT

市場價：

7320元

優(yōu)惠價：

顆粒酶B活性檢測試劑盒

Granzyme B Activity Assay Kit

CTLA1

GZMB Activity Assay Kit

GZMB活性檢測試劑盒

基本信息

EC number【EC 號】	200-664-3
NACRES	NA.84
General description【一般描述】	GZMB codes for granzyme B. Granzyme B (gzm B) is a peptidase that induces cytotoxic T lymphocyte (CTL)-mediated DNA fragmentation and apoptosis in allogeneic target cells. It cleaves after aspartic acid residues in substrates. Granzyme B-mediated release of mitochondrial cell death factors are required for the activation of caspase-3. Furthermore, the degradation of granzyme B is known to decrease the susceptibility of cancer cells to NK-cell-mediated lysis during hypoxia. Granzyme B activity assays can be used for studying T cell immunity, CTL responses, cell-mediated cytotoxicity, and apoptosis. Gzm B is a pro-apoptotic member of the granzyme family. It is a neutral serine protease with Aspase activity. Gzm B is expressed exclusively in the granules of activated cytolytic T cells, natural killer cells and lymphokine-activated killer cells.
Principle【原理】	Granzyme B activity is determined using an enzyme-catalyzed reaction in which the non-fluorescent substrate, Ac-IEPD-AFC, is hydrolyzed resulting in the release of AFC (λex = 380/λem = 500 nm) proportional to the enzymatic activity present. One unit of granzyme B is the amount of enzyme that hydrolyzes 1 pmole of the substrate per minute at 37 ℃.
Components【組分】	組份不可單獨(dú)銷售 Granzyme B Assay Buffer Granzyme B Substrate Granzyme B Positive Control AFC Standard, 1 mM

產(chǎn)品性質(zhì)

usage【用途】	sufficient for 100 fluorometric tests
Detection Method	fluorometric
storage temp.【儲存溫度】	−20℃
Gene Information	human ... GZMB(3002) mouse ... GZMB(14939) rat ... GZMB(171528)
suitability【適用性】	適于檢測生物樣本中的顆粒酶B活性和篩選顆粒酶B的抑制劑。

安全信息

Storage Class Code【儲存分類代碼】

10 - Combustible liquids

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